Featured sailings
American Cruise Lines Featured Sailings
Hand-picked American Cruise Lines departures grouped by itinerary: Mississippi and Columbia River paddlewheel and riverboat voyages, New England and Maine coastal cruises, Southeast Sea Islands, Alaska, Puget Sound and the Great Lakes. Open any itinerary to see every date, then call one of our river cruise experts to confirm the fare for your date.
7 nightsWinter 2026–27 & Spring 2027
Highlights of the Mississippi Cruise
New Orleans, LA round trip
Via Oak Alley, LA, Baton Rouge, LA, Natchez, MS, Vicksburg, MS, St. Francisville, LA
From$3,320per person, double occupancy, Lowest published fare, per person; call for this date
3 departures
Sun, Nov 1, 2026$3,320American Heritage · New Orleans, LA round trip · 7 nightsView sailing → Sat, Mar 20, 2027$3,320American Melody · New Orleans, LA round trip · 7 nightsView sailing → Fri, May 21, 2027$3,320American Heritage · New Orleans, LA round trip · 7 nightsView sailing → 6 nightsWinter 2026–27 & Spring 2027
Columbia River Gorge Cruise
Portland, OR round trip
Via Hood River, OR, The Dalles, OR, Kalama, WA
From$3,725per person, double occupancy, Lowest published fare, per person; call for this date
2 departures
Mon, Mar 22, 2027$3,725American Pride · Portland, OR round trip · 6 nightsView sailing → Thu, Apr 15, 2027$3,725American Harmony · Portland, OR round trip · 6 nightsView sailing → 8 nightsWinter 2026–27 & Spring 2027
Lower Mississippi River Cruise
New Orleans, LA to Memphis, TN
Via Oak Alley, LA, St. Francisville, LA, Natchez, MS, Vicksburg, MS, Cleveland, MS
From$4,295per person, double occupancy, Lowest published fare, per person; call for this date
3 departures
Tue, Nov 3, 2026$4,295American Splendor · New Orleans, LA to Memphis, TN · 8 nightsView sailing → Fri, Mar 19, 2027$4,295American Serenade · New Orleans, LA to Memphis, TN · 8 nightsView sailing → Fri, May 7, 2027$4,295American Melody · New Orleans, LA to Memphis, TN · 8 nightsView sailing → 8 nightsSpring 2027 & Summer & fall 2027
Tennessee Rivers Cruise
Nashville, TN to Chattanooga, TN or Chattanooga, TN to Nashville, TN
Via Paducah, KY, Savannah, TN, Florence, AL, Decatur, AL
From$4,295per person, double occupancy, Lowest published fare, per person; call for this date
2 departures
Tue, Apr 27, 2027$4,295American Symphony · Nashville, TN to Chattanooga, TN · 8 nightsView sailing → Tue, Aug 3, 2027$4,295American Splendor · Chattanooga, TN to Nashville, TN · 8 nightsView sailing → 7 nightsWinter 2026–27
Gulf Coast Cruise
New Orleans, LA to Pensacola, FL or Pensacola, FL to New Orleans, LA
Via Gulfport, MS, Ship Island, MS, Biloxi, MS, Ocean Springs, MS, Mobile, AL
From$4,380per person, double occupancy, Lowest published fare, per person; call for this date
3 departures
Tue, Nov 10, 2026$4,380American Symphony · New Orleans, LA to Pensacola, FL · 7 nightsView sailing → Fri, Feb 12, 2027$4,380American Symphony · New Orleans, LA to Pensacola, FL · 7 nightsView sailing → Fri, Mar 26, 2027$4,380American Symphony · Pensacola, FL to New Orleans, LA · 7 nightsView sailing → 8 nightsSpring 2027 & Summer & fall 2027
Chesapeake Bay Cruise
Baltimore, MD round trip
Via Yorktown, VA, Williamsburg, VA, St. Michaels, MD, Annapolis, MD
From$4,610per person, double occupancy, Lowest published fare, per person; call for this date
2 departures
Fri, May 28, 2027$4,610American Star · Baltimore, MD round trip · 8 nightsView sailing → Fri, Sep 24, 2027$4,610American Independence · Baltimore, MD round trip · 8 nightsView sailing → 8 nightsWinter 2026–27 & Summer & fall 2027
Potomac River & Chesapeake Bay Cruise
Washington, D.C. to Baltimore, MD
Via Williamsburg, VA, Yorktown, VA, Cambridge, MD, St. Michaels, MD, Annapolis, MD
From$4,925per person, double occupancy, Lowest published fare, per person; call for this date
2 departures
Wed, Nov 11, 2026$4,925American Ranger · Washington, D.C. to Baltimore, MD · 8 nightsView sailing → Fri, Jun 4, 2027$4,925American Eagle · Washington, D.C. to Baltimore, MD · 8 nightsView sailing → 8 nightsSpring 2027 & Summer & fall 2027
Maine Coast & Harbors Cruise
Portland, ME to Bangor, ME or Bangor, ME to Portland, ME
Via Bath, ME, Boothbay Harbor, ME, Rockland, ME, Camden, ME, Bar Harbor, ME, Bucksport, ME
From$4,940per person, double occupancy, Lowest published fare, per person; call for this date
4 departures
Fri, May 28, 2027$4,940American Mariner · Portland, ME to Bangor, ME · 8 nightsView sailing → Fri, Jul 9, 2027$4,940American Maverick · Bangor, ME to Portland, ME · 8 nightsView sailing → Fri, Aug 13, 2027$4,940American Mariner · Bangor, ME to Portland, ME · 8 nightsView sailing → Fri, Sep 17, 2027$4,940American Maverick · Bangor, ME to Portland, ME · 8 nightsView sailing → 8 nightsSummer & fall 2027
New England Islands Cruise
Providence, RI round trip
Via New Bedford, MA, Martha's Vineyard, MA, Nantucket Island, MA, Block Island, RI, Newport, RI, Bristol, RI
From$4,940per person, double occupancy, Lowest published fare, per person; call for this date
4 departures
Mon, Jun 7, 2027$4,940American Star · Providence, RI round trip · 8 nightsView sailing → Mon, Jul 26, 2027$4,940American Star · Providence, RI round trip · 8 nightsView sailing → Fri, Aug 27, 2027$4,940American Glory · Providence, RI round trip · 8 nightsView sailing → Mon, Oct 4, 2027$4,940American Star · Providence, RI round trip · 8 nightsView sailing → 8 nightsWinter 2026–27 & Spring 2027
Columbia & Snake Rivers Cruise
Clarkston, WA to Portland, OR or Portland, OR to Clarkston, WA
Via Pendleton, OR, Richland, WA, Hood River, OR, Kalama, WA, Astoria, OR
From$5,055per person, double occupancy, Lowest published fare, per person; call for this date
4 departures
Sun, Nov 1, 2026$5,055American Pride · Clarkston, WA to Portland, OR · 8 nightsView sailing → Fri, May 21, 2027$5,055American Encore · Portland, OR to Clarkston, WA · 8 nightsView sailing → Fri, Jul 16, 2027$5,055American Encore · Portland, OR to Clarkston, WA · 8 nightsView sailing → Fri, Sep 10, 2027$5,055American Anthem · Clarkston, WA to Portland, OR · 8 nightsView sailing → 8 nightsSummer & fall 2027
Upper Mississippi River Cruise
St. Paul, MN to St. Louis, MO or St. Louis, MO to St. Paul, MN
Via La Crosse, WI, Dubuque, IA, Davenport, IA, Hannibal, MO, Alton, IL
From$5,135per person, double occupancy, Lowest published fare, per person; call for this date
3 departures
Fri, Jun 25, 2027$5,135American Melody · St. Paul, MN to St. Louis, MO · 8 nightsView sailing → Fri, Aug 6, 2027$5,135American Serenade · St. Louis, MO to St. Paul, MN · 8 nightsView sailing → Fri, Sep 3, 2027$5,135American Serenade · St. Louis, MO to St. Paul, MN · 8 nightsView sailing → 8 nightsWinter 2026–27 & Spring 2027
Puget Sound & San Juan Islands Cruise
Seattle/ Tacoma, WA to Tacoma, WA
Via Anacortes, WA, Friday Harbor, WA, Cruising the San Juan Islands/Port Angeles, WA, Victoria, BC/Port Angeles, WA, Port Townsend, WA, Poulsbo, WA
From$5,250per person, double occupancy, Lowest published fare, per person; call for this date
4 departures
Thu, Mar 25, 2027$5,250American Ranger · Seattle/ Tacoma, WA to Tacoma, WA · 8 nightsView sailing → Tue, Apr 27, 2027$5,250American Constellation · Seattle/ Tacoma, WA to Tacoma, WA · 8 nightsView sailing → Fri, Jul 9, 2027$5,250American Spirit · Seattle/ Tacoma, WA to Tacoma, WA · 8 nightsView sailing → Sun, Sep 26, 2027$5,250American Constitution · Seattle/ Tacoma, WA to Tacoma, WA · 8 nightsView sailing → 8 nightsWinter 2026–27 & Spring 2027
Arkansas River Cruise
Memphis, TN to Tulsa, OK or Tulsa, OK to Memphis, TN
Via Cleveland, MS, Little Rock, AR, Fort Smith/ Van Buren, AR, Muskogee, OK
From$5,275per person, double occupancy, Lowest published fare, per person; call for this date
2 departures
Sun, Nov 8, 2026$5,275American Serenade · Memphis, TN to Tulsa, OK · 8 nightsView sailing → Fri, May 28, 2027$5,275American Serenade · Tulsa, OK to Memphis, TN · 8 nightsView sailing → 8 nightsSummer & fall 2027
Ohio River Cruise
Louisville, KY to Pittsburgh, PA
Via Madison, IN, Cincinnati, OH, Marietta, OH
From$5,315per person, double occupancy, Lowest published fare, per person; call for this date
3 departures
Sun, Jul 18, 2027$5,315American Symphony · Louisville, KY to Pittsburgh, PA · 8 nightsView sailing → Tue, Aug 3, 2027$5,315American Symphony · Louisville, KY to Pittsburgh, PA · 8 nightsView sailing → Thu, Aug 19, 2027$5,315American Symphony · Louisville, KY to Pittsburgh, PA · 8 nightsView sailing → 8 nightsWinter 2026–27
Great Rivers of Florida Cruise
Jacksonville, FL round trip
Via Green Cove Springs, FL, Jekyll Island/ St. Simons Island, GA, Amelia Island, FL, St. Augustine, FL
From$5,490per person, double occupancy, Lowest published fare, per person; call for this date
2 departures
Sat, Nov 21, 2026$5,490American Eagle · Jacksonville, FL round trip · 8 nightsView sailing → Fri, Feb 5, 2027$5,490American Eagle · Jacksonville, FL round trip · 8 nightsView sailing → 8 nightsSpring 2027
Music Cities Cruise
Memphis, TN to Nashville, TN
Via Paducah, KY, Dover, TN, Clarksville, TN
From$5,635per person, double occupancy, Lowest published fare, per person; call for this date
1 departure
Tue, Apr 20, 2027$5,635American Symphony · Memphis, TN to Nashville, TN · 8 nightsView sailing → 8 nightsWinter 2026–27 & Spring 2027
Southeast Sea Islands Cruise
Amelia Island, FL to Charleston, SC or Charleston, SC to Amelia Island, FL
Via Jekyll Island, GA, St. Simons Island, GA, Savannah, GA, Hilton Head Island, SC, Beaufort, SC
From$5,850per person, double occupancy, Lowest published fare, per person; call for this date
4 departures
Sat, Nov 7, 2026$5,850American Eagle · Amelia Island, FL to Charleston, SC · 8 nightsView sailing → Wed, Feb 3, 2027$5,850American Legend · Charleston, SC to Amelia Island, FL · 8 nightsView sailing → Fri, Apr 2, 2027$5,850American Liberty · Charleston, SC to Amelia Island, FL · 8 nightsView sailing → Fri, Oct 1, 2027$5,850American Liberty · Amelia Island, FL to Charleston, SC · 8 nightsView sailing → 10 nightsSummer & fall 2027
Great Smoky Mountains Cruise
Huntsville, AL to Knoxville, TN or Knoxville, TN to Huntsville, AL
Via Chattanooga, TN, Cruising the Appalachian Mountains, Fort Southwest Point, TN
From$6,120per person, double occupancy, Lowest published fare, per person; call for this date
2 departures
Sat, Jul 10, 2027$6,120American Heritage · Huntsville, AL to Knoxville, TN · 10 nightsView sailing → Mon, Aug 30, 2027$6,120American Heritage · Knoxville, TN to Huntsville, AL · 10 nightsView sailing → 8 nightsSummer & fall 2027
Hudson River Summer Classic Cruise
New York, NY to Albany, NY or Albany, NY to New York, NY
Via Sleepy Hollow, NY, West Point, NY, Kingston, NY, Hyde Park, NY, Catskill, NY
From$6,210per person, double occupancy, Lowest published fare, per person; call for this date
3 departures
Mon, Jun 14, 2027$6,210American Eagle · New York, NY to Albany, NY · 8 nightsView sailing → Mon, Aug 2, 2027$6,210American Eagle · Albany, NY to New York, NY · 8 nightsView sailing → Mon, Sep 20, 2027$6,210American Eagle · New York, NY to Albany, NY · 8 nightsView sailing → 8 nightsSpring 2027 & Summer & fall 2027
Southeast Alaska Cruise
Juneau, AK round trip
Via Haines, AK, Glacier Bay, AK, Petersburg, AK, Cruising the Wrangell Narrows, Wrangell, AK, Endicott Arm, AK, Dawes Glacier
From$6,335per person, double occupancy, Lowest published fare, per person; call for this date
4 departures
Sun, May 30, 2027$6,335American Constitution · Juneau, AK round trip · 8 nightsView sailing → Sun, Jun 27, 2027$6,335American Constitution · Juneau, AK round trip · 8 nightsView sailing → Sun, Jul 25, 2027$6,335American Constitution · Juneau, AK round trip · 8 nightsView sailing → Sun, Aug 29, 2027$6,335American Constitution · Juneau, AK round trip · 8 nightsView sailing → 8 nightsSpring 2027 & Summer & fall 2027
Northeast Harbors Cruise
New York, NY to Boston, MA
Via Sag Harbor, NY, Old Saybrook, CT, New London/Mystic, CT, Newport, RI, Plymouth, MA
From$6,350per person, double occupancy, Lowest published fare, per person; call for this date
2 departures
Fri, May 21, 2027$6,350American Glory · New York, NY to Boston, MA · 8 nightsView sailing → Sun, Jul 25, 2027$6,350American Legend · New York, NY to Boston, MA · 8 nightsView sailing → 8 nightsWinter 2026–27 & Spring 2027
Florida Gulf Coast & Keys Cruise
Tampa, FL to St. Petersburg, FL
Via Marco Island, FL, Key West, FL, Punta Gorda, FL
From$6,575per person, double occupancy, Lowest published fare, per person; call for this date
4 departures
Tue, Nov 3, 2026$6,575American Maverick · Tampa, FL to St. Petersburg, FL · 8 nightsView sailing → Sun, Jan 3, 2027$6,575American Patriot · Tampa, FL to St. Petersburg, FL · 8 nightsView sailing → Sun, Feb 21, 2027$6,575American Patriot · Tampa, FL to St. Petersburg, FL · 8 nightsView sailing → Fri, Apr 16, 2027$6,575American Pioneer · Tampa, FL to St. Petersburg, FL · 8 nightsView sailing → 8 nightsSummer & fall 2027
Hudson River Fall Foliage Cruise
New York, NY to Albany, NY
Via Sleepy Hollow, NY, West Point, NY, Kingston, NY, Hyde Park, NY, Catskill, NY
From$7,190per person, double occupancy, Lowest published fare, per person; call for this date
1 departure
Sat, Sep 25, 2027$7,190American Glory · New York, NY to Albany, NY · 8 nightsView sailing → 8 nightsSpring 2027 & Summer & fall 2027
Cape Codder Cruise
Boston, MA round trip
Via Provincetown, MA, Plymouth, MA, Mass Maritime Academy, MA, Newport, RI, Martha's Vineyard, MA, New Bedford, MA
From$7,415per person, double occupancy, Lowest published fare, per person; call for this date
3 departures
Tue, May 11, 2027$7,415American Maverick · Boston, MA round trip · 8 nightsView sailing → Sat, Jul 10, 2027$7,415American Legend · Boston, MA round trip · 8 nightsView sailing → Fri, Sep 10, 2027$7,415American Navigator · Boston, MA round trip · 8 nightsView sailing → 11 nightsWinter 2026–27 & Spring 2027
American Revolution Cruise
Philadelphia, PA to Washington, D.C. or Washington, DC to Philadelphia, PA
Via Annapolis, MD, St. Michaels, MD, Norfolk, VA, Yorktown/ Jamestown, VA, Williamsburg, VA, Mount Vernon, VA
From$7,765per person, double occupancy, Lowest published fare, per person; call for this date
2 departures
Sun, Nov 1, 2026$7,765American Ranger · Philadelphia, PA to Washington, D.C. · 11 nightsView sailing → Mon, May 17, 2027$7,765American Legend · Washington, DC to Philadelphia, PA · 11 nightsView sailing → 8 nightsSpring 2027 & Summer & fall 2027
Lake Michigan & Upper Peninsula Cruise
Milwaukee, WI round trip
Via Sheboygan, WI, Escanaba, MI, Green Bay, WI, Muskegon, MI
From$7,895per person, double occupancy, Lowest published fare, per person; call for this date
3 departures
Fri, May 21, 2027$7,895American Patriot · Milwaukee, WI round trip · 8 nightsView sailing → Mon, Jul 19, 2027$7,895American Patriot · Milwaukee, WI round trip · 8 nightsView sailing → Thu, Sep 9, 2027$7,895American Patriot · Milwaukee, WI round trip · 8 nightsView sailing → 15 nightsSummer & fall 2027
Mississippi & Cumberland Rivers Cruise
Nashville, TN to New Orleans, LA or New Orleans, LA to Nashville, TN
Via Clarksville, TN, Dover, TN, Paducah, KY, Memphis, TN, Vicksburg, MS, Natchez, MS, Baton Rouge, LA, Oak Alley, LA
From$8,075per person, double occupancy, Lowest published fare, per person; call for this date
3 departures
Tue, Jun 22, 2027$8,075American Symphony · Nashville, TN to New Orleans, LA · 15 nightsView sailing → Tue, Jul 13, 2027$8,075American Splendor · New Orleans, LA to Nashville, TN · 15 nightsView sailing → Tue, Sep 21, 2027$8,075American Splendor · Nashville, TN to New Orleans, LA · 15 nightsView sailing → 15 nightsSummer & fall 2027
Mississippi & Tennessee Rivers Cruise
New Orleans, LA to Huntsville, AL
Via Oak Alley, LA, Baton Rouge, LA, St. Francisville, LA, Natchez, MS, Vicksburg, MS, Memphis, TN, Paducah, KY, Savannah, TN, Florence, AL
From$8,170per person, double occupancy, Lowest published fare, per person; call for this date
1 departure
Sat, Jun 26, 2027$8,170American Heritage · New Orleans, LA to Huntsville, AL · 15 nightsView sailing → 8 nightsSpring 2027 & Summer & fall 2027
Great Lakes & Thousand Islands Cruise
Oswego, NY to Buffalo, NY
Via Clayton, NY, Ogdensburg, NY, Rochester, NY
From$8,395per person, double occupancy, Lowest published fare, per person; call for this date
2 departures
Sun, May 2, 2027$8,395American Patriot · Oswego, NY to Buffalo, NY · 8 nightsView sailing → Sat, Aug 21, 2027$8,395American Patriot · Oswego, NY to Buffalo, NY · 8 nightsView sailing → 15 nightsSummer & fall 2027
Grand Ohio River Cruise
St. Louis, MO to Pittsburgh, PA or Pittsburgh, PA to St. Louis, MO
Via Paducah, KY, Henderson, KY, Evansville, IN, Louisville, KY, Madison, IN, Cincinnati, OH, Maysville, KY, Marietta, OH
From$9,170per person, double occupancy, Lowest published fare, per person; call for this date
3 departures
Fri, Jul 2, 2027$9,170American Melody · St. Louis, MO to Pittsburgh, PA · 15 nightsView sailing → Fri, Jul 16, 2027$9,170American Melody · Pittsburgh, PA to St. Louis, MO · 15 nightsView sailing → Fri, Aug 27, 2027$9,170American Symphony · Pittsburgh, PA to St. Louis, MO · 15 nightsView sailing → 15 nightsSpring 2027 & Summer & fall 2027
Alaska Inside Passage Cruise
Tacoma/ Seattle, WA to Skagway, or Juneau, AK to Anacortes, W
Via Anacortes, WA, Friday Harbor, WA, Cruising Strait of Georgia, Cruising Queen Charlotte Strait, Cruising the Inside Passage, Ketchikan, AK, Wrangell, AK, Petersburg, AK, Cruising the Frederick Sound, Glacier Bay National Park, Hain
From$9,200per person, double occupancy, Lowest published fare, per person; call for this date
3 departures
Thu, May 6, 2027$9,200American Ranger · Tacoma/ Seattle, WA to Skagway, · 15 nightsView sailing → Mon, Aug 30, 2027$9,200American Constellation · Juneau, AK to Anacortes, W · 15 nightsView sailing → Fri, Sep 17, 2027$9,200American Ranger · Juneau, AK to Anacortes, W · 15 nightsView sailing → 15 nightsWinter 2026–27 & Spring 2027
East Coast Inland Passage Cruise
Baltimore, MD to Amelia Island, FL or Amelia Island, FL to Washington, D.C
Via St. Michaels, MD, Norfolk, VA, Kitty Hawk, NC, Beaufort, NC/ Morehead City, NC, Wilmington, NC, Charleston, SC, Beaufort, SC, Hilton Head, SC, Savannah, GA, St. Simons Island, GA, Jekyll Island, GA, Fernandina Beach, FL
From$9,910per person, double occupancy, Lowest published fare, per person; call for this date
2 departures
Tue, Nov 3, 2026$9,910American Glory · Baltimore, MD to Amelia Island, FL · 15 nightsView sailing → Fri, May 21, 2027$9,910American Eagle · Amelia Island, FL to Washington, D.C · 15 nightsView sailing → 11 nightsSummer & fall 2027
New England Explorer Cruise
Boston, MA round trip
Via Portland, ME, Rockland, ME, Bar Harbor, ME, Boothbay Harbor, ME, Bath, ME, Gloucester, MA, Newport, RI, Martha's Vineyard, MA
From$10,170per person, double occupancy, Lowest published fare, per person; call for this date
1 departure
Tue, Jun 8, 2027$10,170American Maverick · Boston, MA round trip · 11 nightsView sailing → 15 nightsSummer & fall 2027
Grand Heartland Cruise
St. Paul, MN to New Orleans, LA
Via La Crosse, WI, Dubuque, IA, Davenport, IA, Hannibal, MO, St. Louis, MO, Memphis, TN, Tunica, MS, Vicksburg, MS, Natchez, MS, Baton Rouge, LA
From$12,620per person, double occupancy, Lowest published fare, per person; call for this date
2 departures
Fri, Sep 17, 2027$12,620American Symphony · St. Paul, MN to New Orleans, LA · 15 nightsView sailing → Fri, Sep 24, 2027$12,620American Serenade · St. Paul, MN to New Orleans, LA · 15 nightsView sailing → 15 nightsWinter 2026–27 & Spring 2027
Grand Florida Coast & Keys Cruise
Amelia Island, FL to St. Petersburg, FL or Tampa, FL/St. Petersburg, FL to Amelia Island, FL
Via Green Cove Springs, FL, St. Augustine, FL, Cape Canaveral, FL, West Palm Beach, FL, Key Biscayne, FL, Key West, FL, Marco Island, FL, Punta Gorda, FL
From$12,990per person, double occupancy, Lowest published fare, per person; call for this date
2 departures
Sun, Nov 22, 2026$12,990American Ranger · Amelia Island, FL to St. Petersburg, FL · 15 nightsView sailing → Fri, May 7, 2027$12,990American Pioneer · Tampa, FL/St. Petersburg, FL to Amelia Island, FL · 15 nightsView sailing → 14 nightsSummer & fall 2027
Northwest National Parks
Tacoma, WA round trip
Via Anacortes, WA, Friday Harbor, WA, Cruising the San Juan Islands/ Port Angeles, WA, Victoria, BC/ Port Angeles, WA, Port Townsend, WA, Poulsbo, WA
From$13,090per person, double occupancy, Lowest published fare, per person; call for this date
3 departures
Sat, Jul 31, 2027$13,090American Spirit · Tacoma, WA round trip · 14 nightsView sailing → Tue, Sep 7, 2027$13,090American Constellation · Tacoma, WA round trip · 14 nightsView sailing → Sat, Sep 25, 2027$13,090American Ranger · Tacoma, WA round trip · 14 nightsView sailing → 15 nightsSummer & fall 2027
Grand New England Cruise
Boston, MA round trip
Via Portland, ME, Bath, ME, Boothbay Harbor, ME, Bar Harbor, ME, Bangor, ME, Rockland/Camden, ME, Portsmouth, NH, Gloucester, MA, Provincetown, MA, Newport, RI, Martha's Vineyard, MA, Nantucket Island/Martha's Vineyard, MA, Plymouth,
From$13,190per person, double occupancy, Lowest published fare, per person; call for this date
2 departures
Fri, Jun 4, 2027$13,190American Pioneer · Boston, MA round trip · 15 nightsView sailing → Fri, Aug 13, 2027$13,190American Pioneer · Boston, MA round trip · 15 nightsView sailing → 13 nightsSpring 2027 & Summer & fall 2027
American Great Lakes Cruise
Buffalo, NY to Milwaukee, WI or Milwaukee, WI to Buffalo, NY
Via Toledo, OH, Detroit, MI, Alpena, MI, Sault Ste. Marie, MI, Mackinac Island, MI, Muskegon, MI, Holland, MI
From$13,800per person, double occupancy, Lowest published fare, per person; call for this date
3 departures
Sun, May 9, 2027$13,800American Patriot · Buffalo, NY to Milwaukee, WI · 13 nightsView sailing → Mon, Aug 2, 2027$13,800American Patriot · Milwaukee, WI to Buffalo, NY · 13 nightsView sailing → Thu, Sep 16, 2027$13,800American Patriot · Milwaukee, WI to Buffalo, NY · 13 nightsView sailing → 14 / 15 nightsSpring 2027 & Summer & fall 2027
National Parks & Legendary Rivers
Portland, OR to Clarkston, WA or Clarkston, WA to Portland, OR
Via Astoria, OR, Kalama, WA, The Dalles, OR, Richland, WA
From$14,060per person, double occupancy, Lowest published fare, per person; call for this date
4 departures
Sun, May 30, 2027$14,060American Jazz · Portland, OR to Clarkston, WA · 15 nightsView sailing → Mon, Jul 12, 2027$14,060American Jazz · Clarkston, WA to Portland, OR · 14 nightsView sailing → Sat, Aug 14, 2027$14,060American Encore · Clarkston, WA to Portland, OR · 14 nightsView sailing → Sat, Sep 25, 2027$14,060American Encore · Clarkston, WA to Portland, OR · 14 nightsView sailing → 15 nightsSummer & fall 2027
Alaska National Parks
Juneau, AK round trip
Via Haines, AK, Glacier Bay, AK, Petersburg, AK, Cruising the Wrangell Narrows, Wrangell, AK, Endicott Arm, AK/ Dawes Glacier
From$14,535per person, double occupancy, Lowest published fare, per person; call for this date
3 departures
Sun, Jun 13, 2027$14,535American Constitution · Juneau, AK round trip · 15 nightsView sailing → Sun, Jul 18, 2027$14,535American Constitution · Juneau, AK round trip · 15 nightsView sailing → Sun, Aug 15, 2027$14,535American Constitution · Juneau, AK round trip · 15 nightsView sailing → 15 nightsSummer & fall 2027
New England Fall Foliage Cruise
Portland, ME to New York, NY
Via Bath, ME, Portsmouth, NH, Gloucester, MA, Boston, MA, Martha's Vineyard, MA, Nantucket Island, MA, Newport, RI, Sag Harbor, NY, New London/Mystic, CT, Sleepy Hollow, NY
From$14,730per person, double occupancy, Lowest published fare, per person; call for this date
1 departure
Fri, Sep 17, 2027$14,730American Mariner · Portland, ME to New York, NY · 15 nightsView sailing → 22 nightsSummer & fall 2027
Complete Mississippi River Cruise
New Orleans, LA to St. Paul, MN
Via Oak Alley, LA, Baton Rouge, LA, St. Francisville, LA, Natchez, MS, Vicksburg, MS, Greenville, MS, Tunica, MS, Memphis, TN, Cape Girardeau, MO, St. Louis, MO, Hannibal, MO, Muscatine, IA, Dubuque, IA, Winona, MN, Red Wing, MN
From$14,890per person, double occupancy, Lowest published fare, per person; call for this date
2 departures
Fri, Jun 4, 2027$14,890American Melody · New Orleans, LA to St. Paul, MN · 22 nightsView sailing → Fri, Jun 11, 2027$14,890American Serenade · New Orleans, LA to St. Paul, MN · 22 nightsView sailing → 18 nightsSummer & fall 2027
Grand Alaska National Parks
Juneau, AK round trip
Via Haines, AK, Cruising the Inside Passage, Glacier Bay National Park, AK, Sitka, AK, Cruising the Inside Passage, Frederick Sound, Petersburg, AK, Cruising the Wrangell Narrows, Wrangell, AK, Tracy Arm, AK
From$18,535per person, double occupancy, Lowest published fare, per person; call for this date
1 departure
Tue, Jul 20, 2027$18,535American Constellation · Juneau, AK round trip · 18 nightsView sailing → Fares shown are the lowest published per-person fare for each itinerary as listed by American Cruise Lines, double occupancy, and vary by departure date and stateroom category. Sailings are removed from this page automatically once they depart. Call for the exact fare on the date you want, including port charges and any current air offers.
No featured sailings right now. Call us for the latest offers.
